Agilent 1290 Infinity II LC System

Welcome to the infinitely better liquid chromatography system. Innovative new technology delivers more resolution per time,more sensitivity and more flexibilityThe debate is over. The advantages of smaller particles—speed, resolution and sensitivity—were developed 40 years ago. The technology took a giant step forward in 2003 when Agilent introduced the first totally porous sub-2 μm particle columns, the ZORBAX Rapid Resolution High Throughput (RRHT) columns. The availability of other advanced particle columns provided additional ways to achieve further gains in separation power per time by using higher flow rates. Today, about a dozen vendors offer dedicated UHPLC systems. All of them operate at different pressures, flow rates, system volumes, temperatures and detector sensitivities. So each system suffers from performance limitations for specific column dimensions or particle technology. And methods transferability between hese systems is either impossible or requires redevelopment and revalidation. Here’s why the 1290 Infinity LC is the last word. With the Agilent 1290 Infinity LC, you’re no longer limited in your choice of column dimension, particle type, mobile and stationary phase, flow rate or pressure. Whatever the chromatography requires for optimum performance, the system can handle it, thanks to its unique power range and next-generation technology. This also includes the new ZORBAX Rapid Resolution High Definition (RRHD) 1.8 μm columns—the only columns for up to 1200 bar operation. The 1290 Infinity LC is also the first system to give you a foundation for methods transfer to or from any Agilent or non-Agilent UHPLC or HPLC system. In short, infinite capabilities are available to solve all your HPLC, UHPLC and LC/MS challenges.

Who can argue with that?

Infinitely more powerful Agilent’s new 1290 Infinity Binary Pump gives you maximum chromatographic performance, compatibility and flexibility.Active damping combines with lowest delay volumes—facilitated by propriety multi-layer technology in the new Agilent Jet Weaver mixer—to provide ultra fast gradients and superior LC/UV and LC/MS performance.

Infinitely more sensitive Featuring an innovative optical design—including Agilent Max-Light cartridge flow cells with optofluidic wave guides the new 1290 Infinity Diode Array Detector delivers a new level of UV sensitivity and baseline robustness. For LC/MS, Agilent Jet Stream Thermal Focusing technology significantly increases MS and MS/MS sensitivity by improving the spatial focusing of electro spray droplets. Infinitely more flexible New Agilent Quick-Change valves in the new 1290 Infinity Thermostatted Column Compartment enable resource-saving ultra high-throughput, multi-method and automated method  development solutions. A totally new module—the 1290 Infinity Flexible Cube allows fixed-loop injection mode for ultra fast cycle times, or automatic backflushing of the needle seat for a new benchmark in lowest carryover.


  • Maximize Analytical Efficiency More chromatographic resolution – specially designed components in the sample flow path achieve lowest system dispersion.
  • Higher peak capacity for challenging separations ­– switch easily between single dimension UHPLC and the ultimate chromatographic power of 2D-LC.
  • Lower carryover for uncompromised data quality – multiwash capabilities of the 1290 Infinity II Multisampler reduce carryover to less than 10 ppm even for challenging compounds such as chlorohexidine.
  • Unique detection capabilities - combine lowest detection limits with an ultra-wide dynamic range by using the new 1290 Infinity II HDR- DAD or 1290 Infinity II ELSD.
  • Maximize Instrument Efficiency Faster injection cycles with dual-needle injection and smart overlapped injections offer higher sample throughput
  • Higher sample capacity per bench space – up to 6144 samples within the footprint of a standard Agilent stack.
  • Significantly better usability - dead-volume-free UHPLC fluidic connections can be easily achieved by the revolutionary A-line quick-connect fittings.
  • Flexibility for all applications – due to the wide power, temperature and automatically scalable injection range, gradient options and intelligent system emulation technology.
  • Maximize Laboratory Efficiency Seamless transfer of methods between LCs, regardless of the brand – facilitated by Intelligent System Emulation Technology (ISET) delivering unchanged retention time and peak resolution.
  • Seamless integration in your chromatography data system – Agilent LC instrumentation runs smoother than ever before when controlled through third-party chromatography data systems such as Waters Empower or Thermo Scientific, thanks to the Agilent Instrument Control Framework (ICF).
  • Lower total cost of ownership– select from a variety of tools to achieve lowest cost-per-sample.
  • Software and Informatics

Agilent 1260 Infinity II LC System

Infinitely more confident.

The new 1260 Infinity LC sets higher standards in performance and value to give you more confidence in your results. The 600 bar power range combines with 80 Hz UV detector speeds and up to 10 times higher sensitivity. That‘s true UHPLC performance! At the same time you can run your existing HPLC methods completely unchanged. In short, the best solution for any HPLC or UHPLC application.

And within the price range of a typical HPLC!

  • Raising the HPLC standard 

The 1260 Infinity LC raises the bar in HPLC! With a 600 bar power range up to 5 mL/min for isocratic, quaternary and binary systems  and 200 bar up to 10 mL/min for isocratic and quaternary systems – plus 80 Hz detector speeds and 10 x higher sensitivity, you will reach new levels of versatility,higher resolution and faster separations.

  • 100% HPLC compatibility

On one system you can run your established and validated HPLC methods – unchanged – as well as push UHPLC to new levels of performance.

  • HPLC price – UHPLC performance

The 1260 Infinity LC is priced similar to earlier 1200 Series HPLC Systems and significantly lower than 1200 Series RRLC systems – so you get much more value for your investment.

  • Infinitely more choice

The modular design concept of the 1260 Infinity LC and the wide range of solvent delivery, injection and detection options, allow you to configure a system that matches exactly your needs for chromatographic performance and flexibility.

Whatever your application needs you can be confident of achieving higher quality data and faster results. Mix and match modules to configure your system for:

  •  Analytical LC with binary, quaternary or isocratic elution
  •  Low-flow LC with capillary or nano-scale flow rates
  •  Purification at micro, analytical or prep scale
  • Workflow and application-based LC and LC/MS solutions

for automated method development, multi-methods, walk-up, high capacity or high throughput.

Higher sensitivity means higher productivity 

Boost your lab – tenfold!

Using the same innovative technology that makes the 1290 Infinity LC the most powerful system available, the 1260 Infinity Diode Array Detector now brings up to 10 times higher sensitivity with 80 Hz detection speed to HPLC. Combined with the detector's superior baseline performance means you can cope with the narrowest peaks and lowest detection limits for more confidence in your results and higher productivity in your lab.

Agilent HPLC


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